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Corresponding Author

Mahmod A. Abdulqader

Abstract

Schiff bases exhibit a wide range of biological activities, including antibacterial, antifungal, anticancer, and anti-inflammatory properties. The aim of study was to synthesized 2-amino-benzothiazole derivatives and showed their novel structure leads to potent antimicrobial activity. The Schiff base compounds derived from 6-bromo-4-fluoro-2-aminobenzothazol was prepared from the reaction of 6-bromo-4-fluoro-2-aminobenzothazol compound (W1) with potassium thiocyanate in the presence of bromine. Unsaturated Alpha-Beta (W2-6) compounds were obtained from the reaction of and aromatic benzaldehyd with para -hydroxy acetophenone in a basal medium. The interaction of alpha-beta - unsaturated compounds with 4,6-dichloro-2-aminobenzothiazole gives compounds (W7-11) 4-(1-(4,6-dichlorobenzothiazole-2-El amino) - 3-aryl) phenol. The prepared compounds have been characterized by melting points and some physical properties besides the FTIR, H-NMR spectra and quantitative analysis of elements (C.H.N.). The purity for these compounds was checked by TLC. The result showed the tested compounds (W1-8 have antibacterial activity against Gram-negative bacteria while Compounds (W9-11) showed moderate antibacterial activity against S. aureus and Proteus ssp. In conclusion used the conventional method for the preparation of different substituted 2-aminobenzothiazole derivatives and showed remarkable antibacterial activity; we need further investigation to study their mechanism of actions at the molecular level.

Digital Object Identifier (DOI)

10.70176/3007-973X.1029

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