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Corresponding Author

Wafaa Raji Alfatlawi

Authors ORCID

Wafaa Raji Alfatlawi: https://orcid.org/0000-0002-7266-1233

Abstract

Osteoporosis is defined as a heterogeneous bone disease that leads to weakening in the structure of bones. Bone structure remains dynamic throughout an individual’s life, it undergoes continuous growth and resorption in a specific mechanism called bone turnover. Osteoporosis assumes the perturbation of equilibrium of the growth to destruction towards the destructive away. Bone turnover markers consider as indicators for pathway of bone turning over, it classified into two groups: first group to build the bones, the second group to break it down. By using bio tests and assays, these markers can be evaluated to monitor the activity of the markers also to determine treatment options and efficacy according to this activity. Using these markers in osteoporotic cases can give an advantage for their use in other diseases such as cancer. One hundred Iraqi women participated in this study (50 patients with osteoporosis and 50 as control), Another subgroup included 25 women with type 2 diabetes mellitus (T2DM) and 25 without diabetes. Biochemicals markers were measured in this study vitamin D, Vitamin D-binding Globulin, (VDBG), Calcitriol Receptor (CARE), Bone Gamma-Carboxyglutamic Acid-containing protein (BGLAP). This study aimed to evaluate the effect of bone turnover markers on osteoporosis, our study suggests that diagnosing osteoporotic women by measuring bone markers early through the course of treatment may increase the treatment effectiveness with high quality adjusted life years. DEXA used to get results of Spin Bone Mineral Density and Spine T-score. Results show significant difference in biomarkers p-value ≤ 0.05 and there was correlation between bone turnover markers and severity osteoporosis. Bone turnover parameters act as a good biochemical tool in the treating and monitoring of osteoporosis and this become more popular in the clinical manner. These various parameters could be used to measure the risk of fracture and also treatment determination and effectiveness.

Digital Object Identifier (DOI)

10.70176/3007-973X.1028

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