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Corresponding Author

Mohammed A. Kubas

Authors ORCID

Mohammed A. Kubas: https://orcid.org/0000-0002-6031-2634

Abstract

Neonates have an immature immune system, making them highly susceptible to infections. Treatment failure in newborns may result from antibiotic resistance, a significant challenge in the management of infectious illnesses worldwide. So the main objective of this research was to develop a newborn-specific antibiogram at the University of Science and Technology hospital (USTH) in Sana’a, Yemen. A retrospective analysis was conducted using microbiological data from the USTH database during the period from January 2021 to March 2022, antibiogram was generated and analyzed using the WHONET application. Gram-positive bacteria were the most frequently isolated pathogens in neonates, followed by gram-negative bacteria. The most frequently isolated gram-positive bacteria were Streptococcus spp. and coagulase-negative staphylococci, while the most frequently isolated gram-negative bacteria were Burkholderia cepacia and Klebsiella spp. The most sensitive antibiotics for gram-positive bacteria were vancomycin and linezolid, whereas carbapenem, colistin, and polymyxin B were the most sensitive antibiotics for gram-negative bacteria. High levels of resistance were noted across both bacterial groups, emphasizing the urgent need for updated local antibiograms to guide empirical therapy. These findings can directly inform antibiotic stewardship efforts and contribute to the development of evidence-based neonatal care guidelines in resource-limited settings like Yemen.

Digital Object Identifier (DOI)

10.70176/3007-973X.1037

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