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Corresponding Author

Wafaa Raji Alfatlawi

Authors ORCID

Wafaa Raji Alfatlawi: https://orcid.org/0009-0002-0337-9346

Abstract

Purpose: The glycoprotein molecule known as megalin is present on the proximal renal tubular epithelial cells. With an emphasis on megalin and cubilin levels in T2DM and IR patients, an area that obviously needs more research, this study attempts to give an outline of current knowledge of megalin function in relation to vitamin D and its metabolite (vitamin D receptor and vitamin D binding protein). Materials and Methods: This was a case control comparative study conducted at a endocrine and diabetes center in AL-Imamain Kadumain teaching hospital in Baghdad-Iraq. Study subjects were divided into three groups: 25 with T2DM with age range 42–45 years, 25 with IR with age range 45–47 years, and 28 as healthy controls with age range 42–44 years. The enzyme-linked immunosorbent assay technique used to estimate serum megalin, cubilin, vitamin D status, and insulin while lipid profile and fasting blood sugar measured by using colorimetric enzymatic method. Results: serum megalin and cubilin levels were higher in the diabetic and insulin resistance subjects compared to healthy control. No correlation was found between serum megalin and cubilin with the biochemical parameters measured in this study. Conclusion: we conclude that megalin and cubilin develop vitamin D deficiency. Lack of presence or malfunction of either receptor is linked to their action by binding and a reduction vitamin D, VDR, and VDBP. The distribution of lipids, vitamins, and other nutrients depends on this interaction. Tubular proteinuria and complications with vitamin metabolism can result from defects in either receptor because they interfere with the reabsorption of carrier proteins.

Digital Object Identifier (DOI)

10.70176/3007-973X.1066

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